Craniofacial growth of immature rats following administration of vincristine and doxorubicin

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Craniofacial growth of immature rats following administration of vincristine and doxorubicin.

The aim of the present study was to investigate the possible short-term effect of two anti-neoplastic drugs, vincristine and doxorubicin, on the craniofacial skeleton in young rats. On the basis of findings from pilot experiments, one dose of 0.0375 mg/kg vincristine or 1.0 mg/kg doxorubicin was given parenterally to inbred Long-Evans/Turku rats at 10 or 30 days of age, and followed up until 30...

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ژورنال

عنوان ژورنال: The European Journal of Orthodontics

سال: 2000

ISSN: 0141-5387,1460-2210

DOI: 10.1093/ejo/22.5.545